期刊:PHYTOCHEMISTRY LETTERS ISSN:1874-3900 , 年:2018 . 卷:24 页码:67-70
语种:
English
原文链接:http://dx.doi.org/10.1016/j.phytol.2018.01.012
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- 摘要
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A new thymol type monoterpene, 2 alpha-methoxyl-3 beta-methyl-6-(acetyl-O-methyl)-2,3-dihydrobenzofuran (1), and a new cadinane-type sesquiterpenoid, 1,6-dihydroxy-1-isopropyl-4,7-dimethyl-3,4-dihydronaphthalen-2(1H)-one (2), were isolated from the roots of Ageratina adenophora, along with four known compounds, eupatorenone (3), 3-hydroxymuurola-4,7(11)-dien-8-one (4), 9-oxoageraphorone (5) and (4R,5S)-4-Hydroxy-5-isopropyl-2-methyl-2-cyclohexehone (6). Their structures were determined by spectroscopic methods, including nuclear magnetic resonance (NMR) and mass spectrometry (MS) techniques. These compounds were all isolated from the roots of this plant for the first time. Compounds 1, 3 and 4 showed in vitro bacteriostatic activity against three test Gram-positive bacteria with MIC values ranging from 12.5 to 50 mu g/mL. While, no obvious inhibitory activity was detected for the other compounds.
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关键词
Ageratina adenophora; Monoterpene; Sesquiterpene; Antibacterial activity
- 作者信息
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通讯作者:
Tan, JW , South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangdong Key Lab Innovat Dev & Utilizat Forest P, Coll Forestry & Landscape Architecture, Guangzhou 510642, Guangdong, Peoples R China.; Xu, QL , Guangdong Acad Forestry, Guangdong Prov Key Lab Biocontrol Forest Dis & Pe, Guangzhou 510520, Guangdong, Peoples R China.
作者机构:
[1]
[
Luo, Bi; Dong, Li-Mei; Zhang, Qiang; Liu, Wen-Bin ]
Chinese Acad Sci, South China Bot Garden, Key Lab Guangdong Prov Key Lab Appl Bot, Guangzhou 510650, Guangdong, Peoples R China.
[2]
[
Luo, Bi; Dong, Li-Mei; Zhang, Qiang; Liu, Wen-Bin ]
Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China.
[3]
[
Luo, Bi; Dong, Li-Mei; Zhang, Xu; Zhang, Qiang; Tan, Jian-Wen ︾ ]
South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangdong Key Lab Innovat Dev & Utilizat Forest P, Coll Forestry & Landscape Architecture, Guangzhou 510642, Guangdong, Peoples R China.
[4]
[
Xu, Qiao-Lin ]
Guangdong Acad Forestry, Guangdong Prov Key Lab Biocontrol Forest Dis & Pe, Guangzhou 510520, Guangdong, Peoples R China.
[5]
[
Luo, Bi ]
Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
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作者邮箱:
qlxu@sinogaf.cn
jwtan@scau.edu.cn